The Role of GABA in Anxiety Disorders
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GABA, Anxiety DisordersAbstract
Gamma-aminobutyric acid (GABA) is the primary inhibitory transmitter in the central nervous system (CNS). One third of all CNS neurons are thought to be GABAergic. GABA is present in relatively high concen trations in the spinal cord and in all regions of the brain but does not exist in neurons outside the CNS.
The inhibitory action of GABA on neuronal activity in the CNS counterbalances the action of the excitatory neurotransmitter glutamate (Figure 1). The mutual homeo- stasis between glutamate and GABA works to modulate neuronal excitability and CNS arousal. This balance pre- vents excessive levels of neuronal hyperexcitability, which are known to occur in seizure disorders and pathologic anxiety and angiogenesis.
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License Terms
Ownership and Licensing:
Authors of this research paper submitted to the Journal of Science & Technology retain the copyright of their work while granting the journal certain rights. Authors maintain ownership of the copyright and have granted the journal a right of first publication. Simultaneously, authors agreed to license their research papers under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License.
License Permissions:
Under the CC BY-NC-SA 4.0 License, others are permitted to share and adapt the work, as long as proper attribution is given to the authors and acknowledgement is made of the initial publication in the Journal of Science & Technology. This license allows for the broad dissemination and utilization of research papers.
Additional Distribution Arrangements:
Authors are free to enter into separate contractual arrangements for the non-exclusive distribution of the journal's published version of the work. This may include posting the work to institutional repositories, publishing it in journals or books, or other forms of dissemination. In such cases, authors are requested to acknowledge the initial publication of the work in the Journal of Science & Technology.
Online Posting:
Authors are encouraged to share their work online, including in institutional repositories, disciplinary repositories, or on their personal websites. This permission applies both prior to and during the submission process to the Journal of Science & Technology. Online sharing enhances the visibility and accessibility of the research papers.
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Authors are responsible for ensuring that their research papers do not infringe upon the copyright, privacy, or other rights of any third party. The Journal of Science & Technology and The Science Brigade Publishers disclaim any liability or responsibility for any copyright infringement or violation of third-party rights in the research papers.